General Pathway for One-Pot Synthesis of Trifluoromethyl- Containing 2-Amino-cycloalka[b][1,8]naphthyridines

General Pathway for One-Pot Synthesis of Trifluoromethyl- Containing 2-Amino-cycloalka[b][1,8]naphthyridines

Andrighetto, Rosália; Bonacorso, Helio G.; Navarini, Jussara; Krüger, Nícolas; Martins, Marcos A. P.; Zanatta, Nilo

Abstract:

Among the nitrogenous heterocycles, naphthyridines and their derivatives represent an important class of organic molecules that attract interest due to their exceptionally broad spectrum of biological activities as well as their use as important binding units in the molecular design of synthetic receptors. Naphthyridine derivatives have attracted considerable attention primarily due to the presence of a 1,8-naphthyridine skeleton in many compounds which have been isolated from natural substances and because they exhibit various biological activities. As a heterocyclic moiety, 1,8-naphthyridine also deserves special interest as in its molecule, the arrangement of the nitrogen atoms is optimal for chelation of various metal cations, including lanthanide ions. Considering the importance of trifluoromethylated heterocycles, the purpose of this work is to report the results of a chemical behavior study of the reactions of 2-trifluoroacetyl-1-methoxycycloalkenes 1 with 2,6-diaminopyridine (2,6-DAP).

Among the nitrogenous heterocycles, naphthyridines and their derivatives represent an important class of organic molecules that attract interest due to their exceptionally broad spectrum of biological activities as well as their use as important binding units in the molecular design of synthetic receptors. Naphthyridine derivatives have attracted considerable attention primarily due to the presence of a 1,8-naphthyridine skeleton in many compounds which have been isolated from natural substances and because they exhibit various biological activities. As a heterocyclic moiety, 1,8-naphthyridine also deserves special interest as in its molecule, the arrangement of the nitrogen atoms is optimal for chelation of various metal cations, including lanthanide ions. Considering the importance of trifluoromethylated heterocycles, the purpose of this work is to report the results of a chemical behavior study of the reactions of 2-trifluoroacetyl-1-methoxycycloalkenes 1 with 2,6-diaminopyridine (2,6-DAP).

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DOI: 10.5151/chempro-14bmos-R0008-2

Referências bibliográficas

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• [4] 4 Bonacorso, H. G.; Andrighetto, R.; Krüger, N.; Zanatta, N.; Martins, M. A. P. Molecules, 2011, 16, 2817.

Como citar:

Andrighetto, Rosália; Bonacorso, Helio G.; Navarini, Jussara; Krüger, Nícolas; Martins, Marcos A. P.; Zanatta, Nilo; "General Pathway for One-Pot Synthesis of Trifluoromethyl- Containing 2-Amino-cycloalka[b][1,8]naphthyridines", p-8-8. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0008-2