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There is little research on the possibilities and limitations of digital design, prototyping and manufacturing of architectural components inspired by microscopic plant structures. The hypothesis was that "prototypes of autonomous responsive cell panels can be produced using digital manufacturing by addition and robotics. The objective was to determine the possibilities and limitations of the design, prototyping and manufacture of a responsive cell prototype inspired by the microscopic plant structures of the peel of fruits of Annona Cherimola, Mill and Annona Squamosa, L. (atemoia), Mauritia Flexuosa (buriti), Attalea ssp (babassu coconut), Annona Muricata (soursop) and Annona Squamosa (pine cone or conde fruit). Autonomous responsive cells inspired in plant structures can be produced. But the autonomous responsive cell controlled for sensor-presents itself as an alternative to automatic orientation toward a natural (sun) or artificial lighting source.