Enzimatyc Kinetic Resolution of Hydroxy Oxazolines

Enzimatyc Kinetic Resolution of Hydroxy Oxazolines

Princival, Cleverson R.; Oliveira, Alfredo R. M. de; Comasseto, João V.; Princival, Jefferson L.

Abstract:

Functionalized 2-oxazolines containing stereogenic centers are importants precursors in organic syntesis, particularly in the synthesies of substituted lactones. The enzimatic kinetic resolution is a tool widely used to obtain enriched enantiomericaly compounds. In addition, secondary alcohols are efficiently resolved by kinetic resolution. In the present work, we developed a synthetic route where hydroxyl 2-oxazolines were submited to kinetic resolution. This class of compounds could be used in synthesis of bioactive chiral lactones.

Functionalized 2-oxazolines containing stereogenic centers are importants precursors in organic syntesis, particularly in the synthesies of substituted lactones. The enzimatic kinetic resolution is a tool widely used to obtain enriched enantiomericaly compounds. In addition, secondary alcohols are efficiently resolved by kinetic resolution. In the present work, we developed a synthetic route where hydroxyl 2-oxazolines were submited to kinetic resolution. This class of compounds could be used in synthesis of bioactive chiral lactones.

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DOI: 10.5151/chempro-14bmos-R0339-1

Referências bibliográficas

• [1] 1 Curtis, M. D.; Shiu, K.; Butler, W. M. e Huffmann, J. C. J. Am. Chem. Soc. 1986, 108, 3335.
• [2] 2 Curtis, M. D.; Shiu, K.; Butler, W. M. e Huffmann, J. C. J. Am. Chem. Soc. 1986, 108, 3335.
• [3] 3 Clososky, G. C.; Costa, C. E.; Missio, L. J.; Cass, Q. B.; Comasseto, J. V. Synth. Commun. 2004, 34, 817.
• [4] 4 Weeler, J. W.; Evans, S. L.; Blum, M. S.; Velthius, H. H. V.; Camargo, J. M. F. Tetrahedron Lett. 1976, 45, 4029.

Como citar:

Princival, Cleverson R.; Oliveira, Alfredo R. M. de; Comasseto, João V.; Princival, Jefferson L.; "Enzimatyc Kinetic Resolution of Hydroxy Oxazolines", p-339-339. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0339-1