Abstract:

Thiazolidinones are important five-membered heterocycles that have valuable biological activities in the medicine chemistry. Recently, we published an efficient, solvent free improved synthesis of 2- (alkyl/aryl)-3-arylamino-1,3 thiazolidin-4-ones from hydrazones. In our research program, there is also an interest in improving the methodologies for the preparation of such heterocycles by non-traditional conditions like sonocatalysis. Ultrasound irradiation has been utilized to accelerate a number of synthetically useful reactions during the last few years. In continuation of our studies, the aim of this paper is the sonocatalysis synthesis of heterocyclic thiazolidinones from the cyclocondensation reaction of piperonilamine, arenealdehydes and mercaptoacetic acid.