Design and synthesis of triazole-chalcones.

Design and synthesis of triazole-chalcones.

Silva, Marina Goulart da; Silva, Graziele Diniz da; L.Veber, Clebson; Barison, Andersson; Viana, Gustavo H. R.; Villar, José Augusto F. P.

Abstract:

Chalcones are important natural products and can also be synthesized by aldol condensation reactions. These compounds have been reported to have a broad range biological activities such as antimalarial, antibacterial, antitumor, antioxidant, antihyperglycemic and anti-HIV. Computational approach suggested that chalcones are potential plasmodial cysteine protease inhibitors. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen bonding and dipole interactions. We describe the synthesis of new chalcones derivatives bearing a 1,2,3-triazole moiety as a new potential antimalarial agents.

Chalcones are important natural products and can also be synthesized by aldol condensation reactions. These compounds have been reported to have a broad range biological activities such as antimalarial, antibacterial, antitumor, antioxidant, antihyperglycemic and anti-HIV. Computational approach suggested that chalcones are potential plasmodial cysteine protease inhibitors. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen bonding and dipole interactions. We describe the synthesis of new chalcones derivatives bearing a 1,2,3-triazole moiety as a new potential antimalarial agents.

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DOI: 10.5151/chempro-14bmos-R0263-1

Referências bibliográficas

• [1] 1 Attar, S., O’Brien, Z, Alhaddad, H., Golden, M.L.,Calderón- Urrea, A., Bioorganic And Medicinal Chemistry 19 (2011) 2055– 2073.
• [2] 2 Mishra,N.; Arora,P.; Kumar, B.; et al., European Journal of Medicinal Chemistry 2008, 48, 1530-1535.

Como citar:

Silva, Marina Goulart da; Silva, Graziele Diniz da; L.Veber, Clebson; Barison, Andersson; Viana, Gustavo H. R.; Villar, José Augusto F. P.; "Design and synthesis of triazole-chalcones.", p-263-263. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0263-1