Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Deracemization of Baylis-Hillman Adducts by Microbial Whole Cells in Ionic Liquids

Vale, Juliana A. ; Silva, Fabio P. L. ; Junior(PG), Claudio G. L. ; Rodrigues, Jose A. R. ; Vasconcellos, Mario L. A. A. ;

Abstract:

Synthesis of chiral compounds in high enantiomeric excess is one of the targets in synthetic organic chemistry. Deracemization by chemical or biological tools is one the methods that have been known for preparation of optically active alcohols from racemates. In these work, we applied microbial whole cells in the studies of deracemization of seven racemic aromatic Baylis-Hillman adducts (BHA) that show selective activity against Leishmania toxicities.

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Palavras-chave: Deracemization, Baylis-Hillman adducts, Microbial Whole Cell,

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DOI: 10.5151/chempro-14bmos-R0317-2

Referências bibliográficas
  • [1] 1 Faber, K. Biotransformations in Organic Chemistry, 5th ed.; Springer- Verlag: Berlin, 2004.
  • [2] 2 Vasconcellos M.L.A A, et al. Eur. J. Med. Chem. 2009, 44, 1726.
  • [3] 3 Cassol, C.C.; Eberling G.; Ferrera, B.; Dupont J. Adv. Synth. Catalysis 2006,348,24
Como citar:

Vale, Juliana A.; Silva, Fabio P. L.; Junior(PG), Claudio G. L.; Rodrigues, Jose A. R.; Vasconcellos, Mario L. A. A.; "Deracemization of Baylis-Hillman Adducts by Microbial Whole Cells in Ionic Liquids", p. 317 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0317-2

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