Copper(I)-Senelenophene-2-carboxylate Catalyzed Cross- Coupling of Aryl or alkyl Thiols And Aryl Halides

Copper(I)-Senelenophene-2-carboxylate Catalyzed Cross- Coupling of Aryl or alkyl Thiols And Aryl Halides

Nunes, Vanessa Lóren; Oliveira, (PG) Ingryd Cristina de; Barros, Olga S. do Rêgo

Abstract:

Aryl sulfides are important building blocks in organic synthesis since many pharmaceutical compounds have the prevalence of the C-S bond. Transitionmetal catalyzing cross-coupling reactions between Csp2-centers have been extensively used for preparing pharmaceuticals and agrochemical intermediates. Considering the advantages of using copper catalysts, less expensive and toxic than palladium salts, we investigated a new methodology to build a carbon–sulfur bond, without any ligand or co-catalyst. In this way, we present our first results of a copper(I)-senelenophene-2-carboxylate (CuSC) catalyzed cross-coupling reaction between aryl halides and thiols.

Aryl sulfides are important building blocks in organic synthesis since many pharmaceutical compounds have the prevalence of the C-S bond. Transitionmetal catalyzing cross-coupling reactions between Csp2-centers have been extensively used for preparing pharmaceuticals and agrochemical intermediates. Considering the advantages of using copper catalysts, less expensive and toxic than palladium salts, we investigated a new methodology to build a carbon–sulfur bond, without any ligand or co-catalyst. In this way, we present our first results of a copper(I)-senelenophene-2-carboxylate (CuSC) catalyzed cross-coupling reaction between aryl halides and thiols.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0177-1

Referências bibliográficas

• [1] 1Itoh, T.; Mase, T. Org. Lett. 2004, 6, 4587-4590.
• [2] 2Kwong, F. Y.; Buchwald, S. L. Org. Lett. 2002, 4, 3517-3520.
• [3] 3Innitzer, A.; Synlett 2005, 2405-2406

Como citar:

Nunes, Vanessa Lóren; Oliveira, (PG) Ingryd Cristina de; Barros, Olga S. do Rêgo; "Copper(I)-Senelenophene-2-carboxylate Catalyzed Cross- Coupling of Aryl or alkyl Thiols And Aryl Halides", p-177-177. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0177-1