Abstract:

In the search for novel bioactive compounds, natural products isolated from marine organisms show a wealth of pharmacological and structural diversity. Amphidinolide-T, marine macrolide, exhibit extremely potent cytotoxicity against tumor cells lines. These natural products are 19- membered macrolides, possessing seven or eight stereogenic centers, a highly substituted tetrahydrofuran ring, an α−hydroxy ketone, an exocyclic methylene group and a homoallylic ester linkage. Due to its high biological activity and intriguing polyoxygenated structure we became interested in its preparation and designed a chemoenzymatic approach to its C6-C13 fragment, using as starting material cyclohexadienediol 1 produced by biotransformation of toluene, as shown in Fig.1.