Bioreduction of (Z)-3-halo-4-phenyl-3-buten-2-one mediated by Pichia stipitis in ionic liquids

Bioreduction of (Z)-3-halo-4-phenyl-3-buten-2-one mediated by Pichia stipitis in ionic liquids

Zampieri, Dávila S.; Paula, Bruno R. S. de; Zampieri, Luiz A.; Cazetta, Tarcila; Moran, J. Augusto R. Rodrigues e Paulo J. S.

Abstract:

Ionic liquids are substances that are completely composed of ions and are liquid at or close to room temperature. Biocatalysis in ionic liquids media was first reported in 2000. In our studies towards the synthesis of chiral halohydrins using [bmim(BF4)] (water-miscible) and [bmim(PF6)] (water-immiscible), one of the approaches was the bioreduction of the correspondent α-haloenones mediated by Pichia stipitis, so as to generate two stereogenic centers in the same reaction.

Ionic liquids are substances that are completely composed of ions and are liquid at or close to room temperature. Biocatalysis in ionic liquids media was first reported in 2000. In our studies towards the synthesis of chiral halohydrins using [bmim(BF4)] (water-miscible) and [bmim(PF6)] (water-immiscible), one of the approaches was the bioreduction of the correspondent α-haloenones mediated by Pichia stipitis, so as to generate two stereogenic centers in the same reaction.

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DOI: 10.5151/chempro-14bmos-R0280-2

Referências bibliográficas

• [1] 1 van Rantwijk, F. e Sheldon, R. A. Chem. Rev. 2007, 107, 2757-2785.

Como citar:

Zampieri, Dávila S.; Paula, Bruno R. S. de; Zampieri, Luiz A.; Cazetta, Tarcila; Moran, J. Augusto R. Rodrigues e Paulo J. S.; "Bioreduction of (Z)-3-halo-4-phenyl-3-buten-2-one mediated by Pichia stipitis in ionic liquids", p-280-280. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0280-2