Asymmetric reduction of 4-Bromo-Acetophenone using whole cells

Asymmetric reduction of 4-Bromo-Acetophenone using whole cells

Ribeiro, Joyce Benzaquem; Lopes, Raquel de Oliveira; Vechia, Luciana Dalla; Ramos, Aline de Souza; Leite, Selma Gomes Ferreira; Souza, Rodrigo Octavio Mendonça Alves de

Abstract:

Biocatalysis has become an increasingly valuable tool for synthetic chemists. Chiral alcohols with additional functional groups are very important intermediates in the synthesis of enantiomerically pure pharmaceuticals and other important chemicals. Chiral phenylethanols (R or S) are an interesting compounds with a number of potential applications, particularly in the drug industry. These alcohols are used as building blocks for the synthesis of bioactive compounds such as pharmaceuticals, agrochemicals and natural products. In this work, we report the use of 14 microorganisms for the asymmetric reduction of 4-Br-acetophenone.

Biocatalysis has become an increasingly valuable tool for synthetic chemists. Chiral alcohols with additional functional groups are very important intermediates in the synthesis of enantiomerically pure pharmaceuticals and other important chemicals. Chiral phenylethanols (R or S) are an interesting compounds with a number of potential applications, particularly in the drug industry. These alcohols are used as building blocks for the synthesis of bioactive compounds such as pharmaceuticals, agrochemicals and natural products. In this work, we report the use of 14 microorganisms for the asymmetric reduction of 4-Br-acetophenone.

Palavras-chave:

DOI: 10.5151/chempro-14bmos-R0206-1

Referências bibliográficas

• [1] 1 Kurbanoglu, E.B., Zilbeyaz, K., Ozdal, M., Taskin, M., Kurbanoglu, N.I. Bioresource Technology 2010, 101, 3825–3829
• [2] 2 Zilbeyaz, K., Kurbanoglu, E.B. Bioresource Technology, 2008, 99, 1549–1552

Como citar:

Ribeiro, Joyce Benzaquem; Lopes, Raquel de Oliveira; Vechia, Luciana Dalla; Ramos, Aline de Souza; Leite, Selma Gomes Ferreira; Souza, Rodrigo Octavio Mendonça Alves de; "Asymmetric reduction of 4-Bromo-Acetophenone using whole cells", p-206-206. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0206-1