AN APPROACH TO THE SYNTHESIS OF SUBSTITUTED CYCLOPENTENONES WITH POTENTIAL ANTI-INFLAMMATORY ACTIVITY FROM MORITA-BAYLIS-HILLMAN ADDUCT

AN APPROACH TO THE SYNTHESIS OF SUBSTITUTED CYCLOPENTENONES WITH POTENTIAL ANTI-INFLAMMATORY ACTIVITY FROM MORITA-BAYLIS-HILLMAN ADDUCT

Filho, Luis Gustavo de Sousa; Coelho, Fernando

Abstract:

The cyclopentenone prostanoids are derived prostaglandin D2, the latter being a byproduct of the metabolism of arachidonic acid in inflammation. The cyclopentenone core play several biological activities, namely: anti-inflammatory, anticancer and antiviral. Due to the biological importance of this structural motif, we began a research project aimed at synthesizing some potentially anti-inflammatory cyclopentenone derivatives using a Morita-Baylis- Hillman adduct as substrate. So, we described herein a new approach for the construction of substituted cyclopentenone derivatives. These cyclopentenones present in their structures some requirements to deliver anti-inflammatory activity.

The cyclopentenone prostanoids are derived prostaglandin D2, the latter being a byproduct of the metabolism of arachidonic acid in inflammation. The cyclopentenone core play several biological activities, namely: anti-inflammatory, anticancer and antiviral. Due to the biological importance of this structural motif, we began a research project aimed at synthesizing some potentially anti-inflammatory cyclopentenone derivatives using a Morita-Baylis- Hillman adduct as substrate. So, we described herein a new approach for the construction of substituted cyclopentenone derivatives. These cyclopentenones present in their structures some requirements to deliver anti-inflammatory activity.

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DOI: 10.5151/chempro-14bmos-R0255-1

Referências bibliográficas

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Como citar:

Filho, Luis Gustavo de Sousa; Coelho, Fernando; "AN APPROACH TO THE SYNTHESIS OF SUBSTITUTED CYCLOPENTENONES WITH POTENTIAL ANTI-INFLAMMATORY ACTIVITY FROM MORITA-BAYLIS-HILLMAN ADDUCT", p-255-255. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0255-1