A New Method to Prepare 3-Alkyl-2-hydroxy-1,4- naphthoquinones. Synthesis of Lapachol and Phthiocol.

A New Method to Prepare 3-Alkyl-2-hydroxy-1,4- naphthoquinones. Synthesis of Lapachol and Phthiocol.

Rocha, David R. da; Ferreira, Sabrina B.; Carneiro, José Walkimar M.; Santos, Wilson C.; Ferreira, Vitor F.

Abstract:

Alkyl-1,4-naphthoquinones constitute an important group of compounds that present some types of biological activity. 3-Substituted-2-hydroxy-1,4- naphthoquinones such as lapachol (1) exhibit a broad spectrum of activities. Lapachol (1) is also widely used by the scientific community as a raw material for the synthesis of various bioactive derivatives and analogues, with _-lapachone (2) being one of the main lapachol derivatives. For this reason, the isolation, structure elucidation and synthesis of 2-hydroxy-3-alkyl-1,4- naphthoquinones, especially lapachol, has attracted a lot of attention.

Alkyl-1,4-naphthoquinones constitute an important group of compounds that present some types of biological activity. 3-Substituted-2-hydroxy-1,4- naphthoquinones such as lapachol (1) exhibit a broad spectrum of activities. Lapachol (1) is also widely used by the scientific community as a raw material for the synthesis of various bioactive derivatives and analogues, with _-lapachone (2) being one of the main lapachol derivatives. For this reason, the isolation, structure elucidation and synthesis of 2-hydroxy-3-alkyl-1,4- naphthoquinones, especially lapachol, has attracted a lot of attention.

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DOI: 10.5151/chempro-14bmos-R0061-1

Referências bibliográficas

• [1] 1 Santos, A. F.; Ferraz, P. A. L.; Pinto, A. V.; Pinto, M. C. F. R.; Goulart, M. O. F.; Sant'Ana, A. E. G. Int. J. Parasitol. 2000, 30, 1199.
• [2] 2 Hussain, H.; Krohn, K.; Ahmad, V. U.; Miana, G. A.; Greend, I. R. Arkivoc 2007, Part II, 145.

Como citar:

Rocha, David R. da; Ferreira, Sabrina B.; Carneiro, José Walkimar M.; Santos, Wilson C.; Ferreira, Vitor F.; "A New Method to Prepare 3-Alkyl-2-hydroxy-1,4- naphthoquinones. Synthesis of Lapachol and Phthiocol.", p-61-61. In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 23184043, DOI 10.5151/chempro-14bmos-R0061-1