Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Total synthesis of targretin via palladium catalyzed crosscoupling reaction of a vinyl organozinc intermediate

Jr., Palimécio G. Guerrero ; Oliveira, Paulo R. de ; Baroni, Adriano C. M. ; Marques, Francisco A. ; Hurtado, Gabriela R. ; Dabdoub, Miguel J. ;

Abstract:

In the last two decades, retinoids as isotretinoin, etretinate and acitretin have been utilized in treatment of primary cutaneous T-cell lymphoma (CLTC) showing modest response in rats. However, the bexarotene (targretin®) 1 emerged as a potent and highly selective ligand for the retinoid X receptors (RXRs) applied in human patients to combat the CLTC, which have become a serious public health problem.

Abstract:

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Palavras-chave: targretin, anticancer, synthesis, paladdium-cross coupling reaction,

Palavras-chave: ,

DOI: 10.5151/chempro-14bmos-R0324-1

Referências bibliográficas
  • [1] 1Abbott, R. R.; Whittaker, S.L. ; Morris, R.; Scarisbrick, J. J. Brit. J. Dermat. 2009, 160, 1299.
  • [2] 2Howe, L. R. Clin. Cancer Res. 2007, 13, 5983.
  • [3] 3Boehm, M.; Zhang, L.; Badea.B. A. J.Med. Chem.1994, 37, 2930.
  • [4] 4 Gao, F.; Hoveyda, A. H. J. Am. Chem. Soc. 2010, 132,10961.
  • [5] 5Dabdoub,M. J. Dabdoub, V. B.; Marino, J. P. Tetrahedron Lett. 2000, 41,433.
Como citar:

Jr., Palimécio G. Guerrero; Oliveira, Paulo R. de; Baroni, Adriano C. M.; Marques, Francisco A.; Hurtado, Gabriela R.; Dabdoub, Miguel J.; "Total synthesis of targretin via palladium catalyzed crosscoupling reaction of a vinyl organozinc intermediate", p. 324 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0324-1

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