Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Tandem Organocatalytic Functionalization and Fisher Indole Synthesis: A Greener Approach for the Synthesis of Indoles

Feu, Karla S. ; Deobald, Anna M. ; Corrêa, Arlene G. ; Paixão, Marcio W. ;

Abstract:

The indole core is featured in a number of natural products as well as medicinally relevant compounds. Recently, the concepts of organocatalytic sequencial reaction has inspired several research groups to design novel stereoselective strategies for assembling target structure and most importantly, reproducing the rich structural diversity found in natural products. Herein, we describe the application of a new class of organocatalysts in the enantioselective synthesis of indole alkaloids under the principles of green chemistry (Figure 1).

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Palavras-chave: covalent organocatalysis, conjugate addition, indole alkaloids,

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DOI: 10.5151/chempro-14bmos-R0342-1

Referências bibliográficas
  • [1] 1 Bandini,M.; Eichholzer, A. Angew. Chem. Int. Ed. 2009, 48, 9608.
  • [2] 2 Brandau,S.; Landa,A.; Franzén, J.;Marigo, M.; Jørgensen, K. A. Angew. Chem. Int. Ed. 2006, 45, 4305.
Como citar:

Feu, Karla S.; Deobald, Anna M.; Corrêa, Arlene G.; Paixão, Marcio W.; "Tandem Organocatalytic Functionalization and Fisher Indole Synthesis: A Greener Approach for the Synthesis of Indoles", p. 342 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0342-1

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