Abstract:

Heterocyclic compounds are promising agents in the development of synthetic molecules with bioactivity. Fused heterocyclic structures containing pyrimidine or furan rings exhibited diverse biological activities such as antimicrobial, anti-inflammatory, antiviral and anticancer. The furo[2,3-d]pyrimidines, which are an important class of heterocyclic compounds, have been considered for many years as a model for the discovery of drugs for inhibition of the enzyme dihydrofolate reductase (DHFR). In view of this biological activity, the objective of this work consists on the synthesis of new furo[2,3- d]pyrimidines as potential agents to act as antifolates inhibiting DHFR, which is present in various fungi, bacteria and protozoa. These compounds may be new agents for neglected diseases.