Abstract:

Interest in synthetic organoselenium compounds has been growing since the 1970s, when many reports described the identification of various selenoproteins, which are involved in a wide number of physiological processes in mammals, such as antioxidant defense, thyroid hormone production and immune responses. There are many reports regarding the biological importance of diselenides having amide bond. The presence of amide bond in close proximity of selenium not only improves the biological activity but also improves the stability of the compound2. Thus, according to our interest in bioactive organoselenium compounds, herein, we describe the synthesis of diselenide based picolylamides 1 (Figure 1), as potentially bioactive molecules.