Abstract:

The synthesis of enaminones is a theme of ongoing interest because this class of compound is a versatile intermediate in organic synthesis as well as due to their biological activity. Enaminones are molecules with the conjugated system N-C=C-C=O, and the amine and acyl group lead these compounds to have both reactive effects: electrophilic (blue) and nucleophilic (red). Due to these electronic effects, enaminones are widely used as building blocks for the synthesis of natural products and heterocycles as indoles, carbazoles, quinolines among others. Herein, we disclosure our results concerning the one-pot synthesis of enaminones through the reactions of acyclic β-aryl enones with benzyl azide, with emphasis on synthetic and mechanistic implications.