Abstract:

The 1,3-enyne is an important core structure often found in many naturally occurring and biologically active compounds. In addition, 1,3-enynes are also very useful synthetic intermediates. The Pdcatalyzed Sonogashira reaction is one of the most powerful methods for the synthesis of such compounds. Pd complexes containing phosphine ligands associated with copper(I) iodide are the most widely used catalysts for this reaction. In the past several years, some protocols using copper catalysts have been developed. Recently, we have shown that a catalytic system based on CuI/1,10- phenanthroline efficiently promotes the coupling between phenols or pyrazole with (E)- bromostilbene. Here we present our first results about the coupling of vinyl bromides with alkynes.