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PRODUÇÃO DE COMPOSTOS a-HIDROXIFOSFONATOS OPTICAMENTE ATIVOS UTILIZANDO CÉLULAS ÍNTEGRAS DE MICRORGANISMOS

SATO, L. M.; KITAMURA, T. N.; FARDELONE, L. C.; RODRIGUES, J. A. R.; MORAN, P. J. S.;

Artigo Completo:

As reduções enantiosseletivas dos cetofosfonatos 1a-c por Lactobacillus brevis CCT 3745 forneceram (S)-(-)-((4-clorofenil)(hidroxi)metil) fosfonato de dimetila (S)-(-)-2a, (S)-(-)-((4-metoxifenil)(hidroxi)metil)fosfonato de dimetila (S)-(-)-2b, (S)-(-)-((3,4-dimetoxifenil)(hidroxi)metil)fosfonato de dimetila (S)-(-)-2c e com o uso de Candida albicans CCT 5847 forneceram (R)-(+)-((4-clorofenil)(hidroxi)metil)fosfonato de dimetila (R)-(+)-2a, (R)-(+)-((4-metoxifenil) (hidroxi)metil) fosfonato de dimetila (R)-(+)-2b e (R)-(+)-((3,4-dimetoxifenil) (hidroxi)metil)fosfonato de dimetila (R)-(+)-2c com rendimentos entre 78-90%. Os (S)-(-)- e (R)-(+)-a-hidroxifosfonatos 2a-c são importantes intermediários para síntese de produtos de química fina, agroquímicos e fármacos.

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DOI: 10.5151/chemeng-cobeqic2015-369-33978-263717

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Como citar:

SATO, L. M.; KITAMURA, T. N.; FARDELONE, L. C.; RODRIGUES, J. A. R.; MORAN, P. J. S.; "PRODUÇÃO DE COMPOSTOS a-HIDROXIFOSFONATOS OPTICAMENTE ATIVOS UTILIZANDO CÉLULAS ÍNTEGRAS DE MICRORGANISMOS", p. 1059-1064 . In: Anais do XI Congresso Brasileiro de Engenharia Química em Iniciação Científica [=Blucher Chemical Engineering Proceedings, v. 1, n.3]. ISSN Impresso: 2446-8711. São Paulo: Blucher, 2015.
ISSN 2359-1757, DOI 10.5151/chemeng-cobeqic2015-369-33978-263717

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