Abstract:

Molecules with furanolactones frameworks have been the target of our synthetic studies for same years. Here we report our recent results related to the use of the abundant and low cost disaccharide lactose for the preparation of new furanofurone compounds. Bicycles like the furanofurone 2 and the furano-pirone 3 may present an interesting biological activity, since they have structural similarities with natural products active against human tumor cells. Both 2 and 3 present an α,β-unsaturated carbonyl system, a functional group that, in a general way, may increase some antitumoral properties.