Setembro 2013 vol. 1 num. 1 - Brazilian Meeting on Organic Synthesis 2011

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Expanding the structural diversity of biologically active spirocyclohexadienones from Morita-Baylis-Hillman (MBH) adducts

Martins, Lucimara J. ; Ferreira, Bruno R. Vilachã ; Lancellotti, Marcelo ; Coelho., Fernando ;

Abstract:

Recently we have developed a new strategy for the synthesis of spirocyclohexadienones. Due to the antibacterial and antiproliferative activities showed by these compounds it was necessary to obtain a set of them with great structural diversity in order to establish a broad biological profile of these compounds. In this comunication we describe some modifications in our original sequence which allowed the preparation of new spirocyclohexadienones.

Abstract:

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Palavras-chave: Morita-Baylis-Hillman, Spirocyclohexadienones, Structural Diversity,

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DOI: 10.5151/chempro-14bmos-R0318-1

Referências bibliográficas
  • [1] 1 Ferreira. B. R. V.; Pirovani, R. V.; Souza-Filho, L. G.; Coelho, F.; Tetrahedron, 2009, 65, 7712.
  • [2] Pirovani, R. V.; Ferreira, B. R. V,; Coelho, F. Synlett, 2009, 2333. 3 Zhdankin, V. V.; Stang, P. J.
  • [3] Chem. Rev. 2008, 108, 5299.
  • [4] Amagata, T.; Takigawa, K.; Minoura, K.; Numata, A. eterocycles 2010, 81, 897.
Como citar:

Martins, Lucimara J.; Ferreira, Bruno R. Vilachã; Lancellotti, Marcelo; Coelho., Fernando; "Expanding the structural diversity of biologically active spirocyclohexadienones from Morita-Baylis-Hillman (MBH) adducts", p. 318 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 1, Setembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-14bmos-R0318-1

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