Abstract:

Stilbene and its derivatives have been attracting considerable attention from the scientific community due to its multiple human health benefits, including chemoprevention and antitumor activity. In 2008 our group completed the synthesis of resveratrol 1, DMU-212 2 (figure 1) and other stilbene derivatives using as key step the Matsuda-Heck arylation. Although effective, we had to rely on benzonitrile as the ideal solvent to achieve high yields and stereoselectivity. Our main goal with this study was the preparation of these derivatives using even more practical and greener conditions.