Abstract:

The chemistry involving selenium is essential for maintaining the life of aerobic organisms, in particular because of the protective antioxidant enzyme glutathione peroxidase (GPx), which protects the body from toxic peroxides. Inspired by the GPx enzyme, several classes of new selenium-based compounds have been prepared for biological studies. On the other hand, ionic liquids are distinguished by their known catalytic abilities from their high salvation capability, as well as water solubility. Inspired by these properties of ionic liquids and the application range (range of bilogical application of) of biological selenium compounds we planned in this work the synthesis of a new series of ionic liquids containing selenium with new potential biological activitys (Figure 1). Besides, in our strategy, the diselenides designed should contain heteroatom (N or O) in the favorable position to chelate with Se atom, as well as good solubility in water.