Abstract:

Aryl sulfides are important building blocks in organic synthesis since many pharmaceutical compounds have the prevalence of the C-S bond. Transitionmetal catalyzing cross-coupling reactions between Csp2-centers have been extensively used for preparing pharmaceuticals and agrochemical intermediates. Considering the advantages of using copper catalysts, less expensive and toxic than palladium salts, we investigated a new methodology to build a carbon–sulfur bond, without any ligand or co-catalyst. In this way, we present our first results of a copper(I)-senelenophene-2-carboxylate (CuSC) catalyzed cross-coupling reaction between aryl halides and thiols.