Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Bioreduction of Alkynones by Fungus from Brazilian Northeast

Silva, A. B. V. ; Oliveira, J. R. ; Ferreira, J. G. ; Princival, J. L. ; Nascimento, T. L. ; Silva, D. C. V. ; Souza, M. C. ;

Abstract:

The chiral non-racemic propargylic alcohols have been applied as important building blocks in the synthesis of biologically active products. In addition, asymmetric bioreduction of alkynones can be a straightforward approach to obtaining this class of compounds in a high enantiomeric excess. In the last years, the number of works using enzymes of microbial strains as biocatalysts source has increased, mainly due to high catalytic and remarkable selectivity. Although, the Brazilian northeast encompasses a diversity of microorganisms which have not been reported as bioreagents. Therefore, the manly objective of this work was to investigate the biocatalytic potential of the fungi Penicillium verruculosum, Xylaria sp and of the genus Trichoderma in the asymmetric reduction of alkynones.

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Palavras-chave: propargylic alcohol, biocatalysis, fungi,

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DOI: 10.5151/chempro-15bmos-BMOS2013_201391419538

Referências bibliográficas
  • [1] 1(a)-Schubert, T.; Hummel, W.; Kula, M. R.; Müller, M.; Eur. J. Org. Chem. 2001, 66, 418(b)-Matsuda, T. Yamanaka, R. Nakamura, K. Tetrahedron: Asymmetry, 2009, 20, 513.
  • [2] 2Hu, S.; Hager, L. P. J. Am. Chem. Soc. 1999, 121, 87
  • [3] 3(a)-Midland, M. ; J. Org. Chem., 1975, 40, 2250. (b)-Caliendo, G.; Fiorino, F. Perissutti, E.; Severino, B.; Gessi, S.; Scolaro, D.; Cattabriga, E.; Borea, P. A.; Santagada, V.; Eur. J. Pharm. Sci., 2002, 16, 15.
  • [4] 4 (a)-Mandai, H.; Murota, K.; Mitsudo, K.; Suga, S.;Org. Lett., Vol. 14, 13, 3486, 2012.(b)-Blake, A. Cunningham, A.; Ford, A. Teat, S. J. Woodward, S.; Chem. Eur. J. 2000, 6, 19
  • [5] 5(a)- Mathews, C. J.; Taylor, J.; Tyte, M. J.; Worthington, P. A.:. Synlett, 2005, 538. (b)-Bassora, B. K.; Costa, C. E.; Gariani, R. A. Comasseto, J. V. Santos, A. A.; Tetrahedron Lett., 2007, 48, 148 (c)-Kurangi, R. F.; Tilve, S. G. Blair, I. A. ; Lipids, 2006, 41, 877.
Como citar:

Silva, A. B. V.; Oliveira, J. R.; Ferreira, J. G.; Princival, J. L.; Nascimento, T. L.; Silva, D. C. V.; Souza, M. C.; "Bioreduction of Alkynones by Fungus from Brazilian Northeast", p. 82 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201391419538

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