Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

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Asymmetric synthesis of pyranocumarins under greener conditions

Monteiro, J. L. ; Torre, A. F. ; Paixão, M. P. ; Corrêa, A. G. ;

Abstract:

Coumarins, in particular pyranocoumarins, are known as potent inhibitors of acetylcholinesterase enzyme primarily responsible for neurodegenerative disorders such as Alzheimer's disease. Rueping et al. reported the asymmetric synthesis of pyranocoumarins using the Jørgensen–Hayashi organocatalyst (20 mol%) in dichloromethane at 10 oC for 48-96 h. The study and development of new methodologies for faster, greener, and more selective synthesis of bioactive compounds is of great interest. This study aims to explore the asymmetric synthesis of pyranocoumarins under eco-friendly reaction conditions.

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Palavras-chave: Pyranocumarins, asymmetric synthesis, Alzheimer´s disease, organocatalysis,

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DOI: 10.5151/chempro-15bmos-BMOS2013_2013101414540

Referências bibliográficas
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  • [2] 2 Rueping, M.; Merino, E.; Sugoino, E.; Adv. Synth. Catal. 2008, 350, 2127.
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  • [4] 4 Deobald, A. M.; Corrêa, A. G; Rivera, D. G; Paixão, M. P. Org. Biomol. Chem. 2012, 10, 7681.
Como citar:

Monteiro, J. L.; Torre, A. F.; Paixão, M. P.; Corrêa, A. G.; "Asymmetric synthesis of pyranocumarins under greener conditions", p. 130 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_2013101414540

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