Dezembro 2013 vol. 1 num. 2 - Brazilian Meeting on Organic Synthesis 2013

Abstract - Open Access.

Idioma principal

Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib

Lopes, Raquel de Oliveira ; Reichart, Benedikt ; Glasnov, Toma ; Kappe, C. Oliver ; Kroutil, Wolfgang ; Miranda, Leandro Soter de M. e ; Leal, Ivana Correa R. ; Souza, Rodrigo O. M. A. de ;

Abstract:

The odanacatib (1) (Figure 1) is a specific inhibitor of cathepsin K acting as an antiresorptive agent that preserves bone-formation for the osteoporosis treatment. The clinical trial (phase III) of odanacatib (1) accomplished early due to the potencial efficacy, safety and favorable benefit-risk profile. By considering the important role of odanacatib (1) for the osteoporosis treatment, the aim of this work is to develop new biocatalysts synthetic routes for building blocks of 1 by using microwave and continuous flow as strategy tools for reaction process optimization

Abstract:

Palavras-chave: Odanacatib, Biocatalysis, Sukuzi-Miyaura coupling,

Palavras-chave:

DOI: 10.5151/chempro-15bmos-BMOS2013_201391717510

Referências bibliográficas
  • [1] 1 Gauthier, J. Y. et al. Bioorg. Med. Chem. Lett. 2008, 18, 923-928.
  • [2] 2 O’SHEA, P. D. et al. J. Org. Chem. 2009, 74, 1605-1610.
  • [3] 3 Has Merck Found The Heir To Fosamax?". Forbes. 2012-07-11. Retrieved 2013-08-18.
  • [4] 4 Bisogno, F. R. et al. Chem. Eur. J. 2010, 16, 11012-11019.
  • [5] 5 Borchert, S. et al. J. Mol. Catal. B: Enzym. 2012, 84, 89–93.
Como citar:

Lopes, Raquel de Oliveira; Reichart, Benedikt; Glasnov, Toma; Kappe, C. Oliver; Kroutil, Wolfgang; Miranda, Leandro Soter de M. e; Leal, Ivana Correa R.; Souza, Rodrigo O. M. A. de; "Asymmetric enzymatic reduction and Suzuki-Miyaura coupling for the synthesis of odanacatib", p. 104 . In: In Blucher Chemistry Proceedings, São Paulo, v. 1, n. 2, Dezembro.2013. São Paulo: Blucher, 2013.
ISSN 2318-4043, DOI 10.5151/chempro-15bmos-BMOS2013_201391717510

últimos 30 dias | último ano | desde a publicação


downloads


visualizações


indexações