Abstract:

Optically active epoxy ketones are versatile building blocks for synthesis of several natural products and pharmaceuticals. In this context, the development of efficient methods for the asymmetric epoxidation of α,β-enones is a interesting goal in organic synthesis. In order to achieve these purpose, the enantioselective organocatalysis is an useful tool in the synthesis of building blocks under practical conditions. In this work, we highlight the synthesis and application of a new class of organocatalysts in the enantioselective synthesis of epoxy ketones.