Abstract:

Continuous flow technology has attracted the attention of the organic chemistry community in the last decade, both as an enabling tool to enhance organic synthesis and as a manufacturing method. The continuous flow synthesis of active pharmaceutical ingredients (APIs), which typically involve a significant number of synthetic steps, therefore clearly is a rather complex operation. Atazanavir is one of the most prescribed protease inhibitors in Brazil (and worldwide) and thus a sufficient and cost effective supply to Atazanavir is of prime importance. The retrosynthetic analysis for the Atazanavir (1) molecule is shown in Figure 1 and reveals an assembly three different building blocks.