Abstract:

α,β-unsaturated diazoketones have been proven to be interesting multi-functional building blocks in organic chemistry. An interesting reaction, little studied with these building blocks is the Aza-Michael reaction. This reaction consists in an important tool for the formation of C-N bonds and is extremely useful in the synthesis of natural products. In this context, we studied the Michael reaction with α,β- unsaturated diazoketones and its application in the synthesis of barmumycin (a natural product with antitumor activity).